Two Sisters Creole Kitchen

Discover authentic Creole cuisine at Two Sisters Creole Kitchen in Picayune, MS. Savor flavorful red beans, gumbo, jambalaya, crawfish, and more. Call +1 601-749-9117 for a delicious taste of soulful Cajun food today!

Welcome to Two Sisters Creole Kitchen

Taste the Difference.

Two Sisters Creole Kitchen
Two Sisters Creole Kitchen
Two Sisters Creole Kitchen
Two Sisters Creole Kitchen

Nestled in Picayune, Mississippi, Two Sisters Creole Kitchen serves a delightful blend of Creole, Cajun, and soul food. This cozy restaurant welcomes diners with the enticing aromas of gumbo, jambalaya, and po-boys. Reflecting the vibrant culture of Louisiana, the kitchen prides itself on delivering authentic flavors curated from cherished family recipes. Whether you visit for a quick lunch or a leisurely dinner, the warm ambiance and friendly staff create a welcoming experience that feels like home. Conveniently located at 119 Hwy 11 S, it’s a perfect spot for locals and travelers alike seeking a taste of the South.

Directions & Reservations

Plan Your Visit

Address

119 Hwy 11 S, Picayune, MS 39466, United States

Phone

+1 601-749-9117

Social Media

About

The Culinary Story

Two Sisters Creole Kitchen
Two Sisters Creole Kitchen
Two Sisters Creole Kitchen
Two Sisters Creole Kitchen

Two Sisters Creole Kitchen stands as a culinary beacon in Picayune, MS, emphasizing Creole cuisine that brings people together. Located off Highway 11, the restaurant boasts an inviting charm with its bright decor and friendly staff, ensuring a warm atmosphere. Here, every meal is a tribute to the roots of Southern cooking, steeped in tradition yet unafraid to innovate.

The menu is designed to highlight the unique flavors of Creole and Cajun dishes. For those craving seafood, the Mega Seafood Platter is a must-try, featuring an array of fresh catches that truly reflect the local fishing culture. Meanwhile, non-seafood lovers will relish their chicken linguine, bursting with flavor and expertly prepared to please the crowd. For a casual starter, stuffed jalapenos offer a perfect kick, setting the tone for an adventurous meal.

Business thrives during peak lunch hours, especially on Tuesdays around noon, when the kitchen buzzes with food preparation and laughter from satisfied guests. The restaurant maintains a high energy during these busy times, and it’s not uncommon to see regulars catching up over a bowl of jambalaya or a hearty po-boy. With the menu frequently updated, diners are encouraged to discover new tastes in this vibrant and welcoming space. It’s not just a meal; it’s an experience that transcends barriers and brings the community together around comfort food.

In addition to the delicious menu, Two Sisters Creole Kitchen participates in local events, fostering connections within the Picayune community. Whether it’s charity fundraisers or local festivals, showing support for the town adds a special touch to its identity. Through authentic flavors and cherished traditions, this establishment is more than just a restaurant; it's a community staple reflecting the spirit of the region.

Work Hours

Availability and Service Times

  • SundayClosed
  • Monday10:30 AM-6 PM
  • Tuesday10:30 AM-6 PM
  • Wednesday10:30 AM-6 PM
  • Thursday10:30 AM-6 PM
  • Friday10:30 AM-6 PM
  • SaturdayClosed

Two Sisters Creole Kitchen features a diverse menu that caters to every palate. Highlights include their signature red beans and rice, rich gumbo packed with flavor, succulent pork chops, and the heralded crab cakes. Each dish showcases a blend of spices and ingredients sourced locally, ensuring a fresh dining experience. The restaurant also offers casual seating, perfect for social gatherings or family outings, fostering a sense of community among patrons.

Signature dishes are complemented by daily specials that encourage repeat visits.

The lunch rush between 11 AM and 2 PM draws in food lovers seeking hearty portions at reasonable prices, averaging just $10.93. On busy days like Tuesday, when the capacity hits 100% at noon, be prepared for an atmosphere buzzing with energy and laughter.

Two Sisters Creole Kitchen

The exterior of Two Sisters Creole Kitchen captures the essence of the South with its inviting façade. Colorful signage welcomes guests, while the small outdoor seating area offers a relaxed vibe perfect for enjoying Creole delights under the Mississippi sun. The charm of the exterior mirrors the warmth found within.

The casual, homey atmosphere encourages patrons to linger longer, whether chatting with friends or taking in the rich aromas wafting from the kitchen. This blend of comfort and community creates an ideal setting for food lovers to share in their passion for Southern cuisine.

Guestbook & Reviews

Experience Through Their Eyes

Went to eat at Two Sister's Restaurant in Picayune on Jan. 28, 2026. Met the Owner, Ms. Victoria. Had some delightful crawfish etoufee with two sides: rice and corn, with toast. Crawfish etoufee was delightfully toothsome and fried green tomatoes were fresh and fried perfectly! The thing that I liked most about the crawfish etoufee: it was delightfully Creole spiced without being too spicy hot. Loved it. Thank you, Ms. Victoria.

M
M B.

First time here. Very homey and comfortable. Staff was super nice. Food was delicious. Belinda was our server..loved her.

D
Debra W.

The food portions are large and prices are reasonable. Also, the food taste delicious. The service was good too. I had the crab cakes with seafood cream sauce and jambalaya rice.

S
Sheri H.

The best home cooked meal you can get! Tons of flavor and everything was cooked to perfection!

T
Tim W.

Great service, amazing food. Almost licked my plate clean!

R
Rahsaan M.

Wish I had known about this place years ago while visiting my family in Picayune! Wonderful food at an affordable price! Excellent staff and service for this late arriving bunch of hungry folks and kiddos! Will see you again when next in the area. Blessings for 2026

V
Valerie D.